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Carboplatin AUC Calculator
Carboplatin AUC - Information
This calculator estimates the total Carboplatin dose in mg for an individual using the Calvert formula:
This calculator will make all the necessary conversions based on the parameters entered
Serum creatinine will be rounded to 0.7 for those patients with abnormally low serum creatinine (Cr) < 0.7.
Adjusted body weight (AjBw) and dose will be displayed for overweight or obese patients (BMI ≥ 25 kg/m2).
The FDA has recommended that providers consider capping the dose of Carboplatin for desired exposure (AUC) to avoid potential toxicity due to overdosing. The maximum dose is based on a GFR estimate that is capped at 125 mL/min for patients with normal renal function.
- For a target AUC = 6, the maximum dose is 900 mg
- For a target AUC = 5, the maximum dose is 750 mg
- For a target AUC = 4, the maximum dose is 600 mg
The recommended Dose field will strictly follow the information above.
However, all calculations will be presented under the "Other calculations" sections to aid the clinicans with their decision.
Cockcroft-Gault Equation to estimate Creatinine Clearance Rate (eCCr):
Where Constant is 1.23 for males and 1.04 for females.
Ideal Body Weight:
Sex is required
Age is required
Weight is required
Height is required
Serum Creatinine is required
Target AUC is required